Effect of Fenugreek on Carbohydrate and Lipid Metabolisms of Rats Treated With Cypermethr in Combined With High-Fat-Diet and Low Dosestreptozotosin

Document Type : Original Article

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Agric. Biochem. Dept., Fac. Agric., Banha Univ., Banha, Egypt

Abstract

The aim of the present study was to use the new model for the type 2 diabetes using high-fat diet (HFD) in combination with low dose of streptozotosin (STZ, 35mg/kg) and investgate the influences of cypermethr in (pesticide) toxicity which attenuated by fenugreek soaked seeds, etiolated sprouts (3 days old) and microgreen (10 days old) semi-modified diet (SMD) on experimental rats.  From the obtained results, it can be indicated that the high fat feeding in combination with a low doses of STZ together with cypermthrin ingestion increased blood glucose and LDL-c in the paralled with decreasing rats body weight gain. The treatment by fenugreek etiolated sprouts (10%) semi-modified diet for HFD with STZ as semi-modified diets improved significantly the rats body weight gain (BWG) and lipids profile, while feeding on fenugreek microgreen readjusted significantly blood glucose, BWG, total cholesterol and HDL-c but decreased LDL-c levels. On the other hand, the using of soaked fenugreek seed semi-modified diets increased only BWG but decreased LDL-c. The hyperglycemia increased the total cholesterol content under the treatment with fenugreek microgreen semi-modified diets which showed more pronounced increment in combination with cypermethrin. The accomplished results showed that cypermethrin led to a hyperglycemic activity in HFD/STZ model rats. Soaking fenugreek seeds improved lipid metabolism compared with fenugreek and microgreen which non-toxic in doses given to rats in the present study over 28 days period.

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