Evaluation of the Effect of Milk Thistle Extract on Gamma Irradiated Rats

Document Type : Original Article

Authors

1 Biochemistry, Faculty of agriculture

2 Biochemistry department, Faculty of Agriculture at Moshtohor, Benha University

3 Agriculture Biochemistry Department, Faculty of Agriculture, Benha University, Egypt

4 Egyptian atomic energy authority

Abstract

The milk thistle (Silybum marianum) is a good source of phenolic and flavonoid compounds that act as natural antioxidants. The present study was planned to investigate the protective role of milk thistle (MT) against γ-radiation (six gray) induced hepatotoxicity and renal toxicity. Liver markers, kidney function, lipid profile, and malondialdehyde (MDA) as an oxidative stress marker, and antioxidant enzyme (CAT, SOD, and GSH) were measured after radiation. The obtained results showed that oral administration of milk thistle extract (200mg /kg B.w) orally daily for four weeks caused significantly decrements in the activities of transaminase enzymes  in the serum of rats, and  significantly decrements in  the total lipids ,triglyceride and total cholesterol levels in serum of irradiated rats. Also caused improvement in kidney function, and significant increments in the antioxidant enzyme (SOD and CAT) and GSH concentration. Significant in decrements total free radical  and MDA in blood and Liver tissues  have happened with irradiated groups .This study suggests that (MT)  has an  antioxidant effect to radio protective effect, this may be  due to its advantage of using (MT) as a source of natural antioxidants against gamma radiation

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Annals of Agricultural Science, Moshtohor
Volume 62, Issue 4
December 2024
Pages 41-50

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