Evaluation of Photochemical Components, Antioxidant Properties and Cytotoxicity Effects of Some Egyptian Algae Extracts on Some Cancer Cells

Document Type : Original Article

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Biochemistry banha

Abstract

In this work, two marine green macro algae are potential (Enteromorpha intestinalis and Ulva lactuca species) as a source of several critical bioactive substances. Bioactive phenolic and flavonoids compounds were explored. Antioxidant properties and anticancer effects, such as cytotoxicity of different extracts of Enteromorpha sp < /em> and Ulva lactuca sp, have been investigated. The methanolic extracts have the most robust free radical activity (91.89 %) as well as ethyl acetate (86.70%), followed by water extract (82.47 %) and hexane extract (77.25 %) of Ulva sp comparedto ascorbic acid as standard (98.16%). Percentage inhibition on free radical scavenging generation by the methanolic extract was found to be increasing in Enteromorpha sp < /em> (83.85 %), followed by water extract (81.14%); ethyl acetate extract (80.56 %) and hexane extract (71.76%). The methanolic extract of Enteromorpha sp < /em> and Ulva sp < /em> yielded data demonstrating a high total phenolic content of 66.8 and 40.3 as mg GAE /g sample, respectively. The Enteromorpha sp < /em> and Ulva sp < /em> extracted with methanol were significantly higher in their content of total flavonoids (49.4 and 32.1 as quercetin mg/g sample, respectively) than the other extracts. The obtained data reveal that methanol extract had the highest anticancer activity. There was no inhibition of all cancer cells of the samples extracted with water. The results showed that this type of algae contains unique and innovative chemical active antitumor components and can act as an antioxidant and anti-carcinogenic agent of the liver and colon for future applications in the pharmaceutical industries.

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